The United States Food and Drug Administration (FDA) has issued its Sentinel Newsletter, which can be read below.
| Each year, Sentinel refreshes its Key Database Statistics to highlight changes in the patient characteristics of the Sentinel Distributed Database. Graphics are used to visualize the composition of the Sentinel System and display the data from our contributing Data Partners that are used to assess the safety of approved medical products. These data are routinely gathered through the use of a distributed program that is run following the approval of each data refresh. Further information can be found on the Sentinel website link here. |
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| This manuscript recently published in the American Journal of Epidemiology describes a project led by Richard Wyss, PhD from the Sentinel Innovation Center. The paper focuses on the use of Lasso regression for large scale Propensity Score (PS) estimation in healthcare database studies. Further information can be found on the Sentinel website link here. |
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The Innovation and Methods Webinar Series is hosted by the Innovation Center (IC) and serves as a platform to engage with experts and innovators around topics related to the IC strategic priorities. The latest information on upcoming webinars will be made available on the Sentinel Website.
Follow the steps below to access the most recent and upcoming webinars series:
1. Go to the Sentinel Initiative website homepage.
2. On the homepage, click on the top bar menu option: News & Events.
3. Click on the Meetings, Workshops, & Trainings tab located on the left vertical menu bar.
4. The Meeting, Workshops & Trainings page displays details for a variety of events, trainings, and webinars.
5. Access webinars information and materials within the 2024 Sentinel Innovation and Methods Seminar Series page. |
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A PRocess Guide for INferential Studies Using Healthcare Data to EvaLuate Causal Effects of Drugs (PRINCIPLED)
On February 29, 2024, Dr. Rishi Desai delivered a presentation on inferential studies using healthcare data to evaluate causal effect. The presentation introduced a stepwise process covering the range of considerations, including 1) Formulating a causal question, 2) Describing the emulation of each component of the protocol, 3) Assessing expected precision and diagnostic evaluations, 4) Planning the assessment, and 5) Completing Inferential analyses, to foster a generation of reliable and reproducible evidence.
Learn more >> |
|  | Data-driven Phenotyping Algorithms for Acute Health Conditions: Applying PheNorm to COVID-19
On March 25, 2024, Dr. Joshua Smith presented on automated phenotyping algorithms that can reduce development time and operator dependence compared to manually developed algorithms. One such approach, PheNorm, has performed well for identifying chronic health conditions, but its performance for acute conditions is largely unknown. We evaluated PheNorm applied to symptomatic COVID-19 disease to investigate its potential feasibility for rapid phenotyping of acute health conditions.
Learn more >> |
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Sentinel Community Building and Outreach Center (CBOC) Training Series |
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CBOC INFORMATIONAL VIDEOS
The Sentinel Community Building and Outreach Center has created informational videos to provide
on-demand resources to become more familiar with Sentinel. Click below to learn more about two
recently released videos. |
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EHR vs. CLAIMS: CBOC explores how claims and EHR data may be used to address different dimensions of a scientific question or problem. This video details the limits and strengths of each identified resource and how they both affect the outcomes of scientific studies.
Click here to watch the video.
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| SENTINEL VIEWS is a data visualization application designed to increase comprehension of the Sentinel System study results. It has been integrated into the existing Sentinel querying and reporting infrastructure, to support the work of the Sentinel System. The Sentinel Views web graphics are interactive and help to visualize results. The tool also includes a public facing dashboard accessible to the general public.
Click here to watch the video. |
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Validity of Inpatient Electronic Health Record-Based Measures of Oxygen-Related Therapy in the United States: Lessons Applicable for Studying COVID-19 Endpoints
Learn more >> |
| | Risk of Arterial and Venous Thrombotic Events Among Patients with COVID-19: A Multi-National Collaboration of Regulatory Agencies from Canada, Europe, and United States
Learn more >> |
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smdi: An R Package to Perform Structural Missing Data Investigations on Partially Observed Confounders in Real-world Evidence Studies
Learn more >> |
| | Drug Safety Surveillance with EHR Data: A Promise Not Yet Fulfilled
Learn more >> |
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COVID-19 Pandemic Related Changes in Healthcare Utilization Among Insured Persons in the US and its Impact on Pharmacoepidemiologic Research
Learn more >> |
| | Monitoring of Safety and Effectiveness of COVID-19 Therapeutics: Aim 1 Protocol Development
Learn more >> |
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Characterization of COVID-19 Genomic Data in Sentinel Distributed Database
Learn more >> |
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